Whether the spray delivery device is a nebuliser, metered-dose inhaler (MDI) or Electronic Nicotine Delivery Systems (ENDS), the use of the particle size testing helps to understand the performance of the device which is an important factor when considering a product’s safety and its effect on the users health.

The size of a particle determines its deposition in the oral cavity and relates to the dose received by tissues and organs, their potential toxicity and their behaviour in the surrounding environment. Aerosols with a larger particle size will be deposited in the oral cavity and throat, whereas smaller particles will enter into the deep lung where diffusion can occur more rapidly. 

At Inter Scientific, we believe in investing in the best testing equipment to produce accurate, quality results for our clients products and ensure they meet all legal requirements. When we invested in our Laser Diffractor to measure particle size, it was no exception to this.

The particle size testing technique used – known as Laser Diffraction – produces accurate real-time results with the ability to determine dynamic changes in spray particle size through unique software. 

This method allows aerosol formulations to be rapidly and accurately screened for the correct spray properties, reducing development times and improving drug delivery, thus assisting in the manufacture / production of a quality and safe product.

Additionally we can assess the impact of different conditions on the particle size, e.g if the user uses a direct lung vape or that of a mouth-to-lung technique. Our methodology also includes the United States pharmacopeia testing methodology for inhaled products involving simulated throat inhalation.

In each vape device, different considerations need to be taken into account when measuring the particle size. For instance, particle size distributions in Electronic Nicotine Delivery Systems (ENDS) aerosols may be affected by several factors including:

These can alter the particle size results forming in a variation in dosage and performance with each vape liquid / device combination.

In summary, particle size testing is the only precise way to measure the performance of any spray delivery device and ensure accurate dosage for the public.
If you would like to find out more about particle testing size contact info@inter-scientific.com today to discover more about what we can do for you.

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